Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular
subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures …

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we
unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic …

Type 1 diabetes mellitus (T1DM) is a disease where destruction of the insulin producing
pancreatic beta-cells leads to increased blood sugar levels. Both genetic and environmental …

Influenza infection and pneumonia are known to cause much of their mortality by inducing
acute respiratory distress syndrome (ARDS), which is the most severe form of acute lung …

Women diagnosed with high-grade serous ovarian cancers (HGSOC) are still likely to
exhibit a bad prognosis, particularly when suffering from HGSOC of the Mesenchymal …

Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of
chemotherapy on CAF populations remains poorly understood. Here we address this …

The tumor microenvironment (TME) components play a crucial role in cancer cells'
resistance to chemotherapeutic agents. This phenomenon is exceptionally fundamental in …

A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often
difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately …