Peripheral nerve repair and regeneration remains among the greatest challenges in tissue
engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are …

Fibers are the building blocks of a broad spectrum of products from textiles to composites,
and waveguides to wound dressings. While ubiquitous, the capabilities of fibers have not …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …

The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel (LGIC) that
plays an important role in cellular calcium signaling and contributes to several neurological …

Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Neutrophil migration to injured and pathogen-infected tissues is a fundamental component
of innate immunity. An array of cellular and molecular events mediate this response to …

BACKGROUND Pain remains the cardinal symptom of endometriosis. However, to date, the
underlying mechanisms are still only poorly understood. Increasing evidence points towards …

Introducing concentration gradients of nerve growth factor (NGF) into conduits for repairing
of peripheral nerve injury is crucial for nerve regeneration and guidance. Herein, combining …

Studying neurite guidance by diffusible or substrate bound gradients is challenging with
current techniques. In this study, we present the design, fabrication and utility of a …