Interleukin (IL)‐6 is a cytokine with pleiotropic functions in different tissues and organs.
Skeletal muscle produces and releases significant levels of IL‐6 after prolonged exercise …

Signal transducer and activator of transcription‐3 (STAT‐3) is one of six members of a family
of transcription factors. It was discovered almost 15 years ago as an acute‐phase response …

Skeletal muscles adapt to increasing workload by augmenting their fiber size, through
mechanisms that are poorly understood. This study identifies the cytokine interleukin-6 (IL-6) …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

In this study, the differentiation of C2C12 cells, a primary line of murine myoblasts, was
investigated by a multiple technical approach. Undifferentiated cells, and those at …

We used a combination of genome‐wide and promoter‐specific DNA binding and
expression analyses to assess the functional roles of Myod and Myog in regulating the …

Skeletal muscle stem cell–derived myoblasts are mainly responsible for postnatal muscle
growth and injury-induced muscle regeneration. However, the cellular signaling pathways …

In this study, we investigated the effects and mechanisms of the pro-inflammatory cytokines
IL-1β and TNF-α on the proliferation and commitment phases of myoblast differentiation …

The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces
proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine …

Myogenic differentiation plays an important role in muscle regeneration and is regulated by
two transcription factor families, MRFs and MEF2, which induce differentiation of myoblasts …