Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases

TS Agidigbi, C Kim - International journal of molecular sciences, 2019 - mdpi.com
Reactive oxygen species (ROS) and free radicals are essential for transmission of cell
signals and other physiological functions. However, excessive amounts of ROS can cause …

The influence of alkaloids on oxidative stress and related signaling pathways

K Macáková, R Afonso, L Saso, P Mladěnka - Free Radical Biology and …, 2019 - Elsevier
Alkaloids have always attracted scientific interest due to either their positive or negative
effects on human beings. This review aims to summarize their antioxidant effects by both …

Clinical implications of oxidative stress and potential role of natural antioxidants in diabetic vascular complications

A Ceriello, R Testa, S Genovese - Nutrition, Metabolism and Cardiovascular …, 2016 - Elsevier
Aims The possible link between hyperglycaemia-induced oxidative stress (OxS) and
diabetic complications is suggested by many in vitro studies. However, not much attention …

Hyperoxia evokes pericyte-mediated capillary constriction

C Hirunpattarasilp, A Barkaway… - Journal of Cerebral …, 2022 - journals.sagepub.com
Oxygen supplementation is regularly prescribed to patients to treat or prevent hypoxia.
However, excess oxygenation can lead to reduced cerebral blood flow (CBF) in healthy …

The human Nox4: gene, structure, physiological function and pathological significance

S Guo, X Chen - Journal of drug targeting, 2015 - Taylor & Francis
Increased generation of reactive oxygen species (ROS) has been implicated in the
pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH …

Cardioprotective potential of vanillic acid

B Yalameha, HR Nejabati… - Clinical and Experimental …, 2023 - Wiley Online Library
Nowadays, cardiovascular diseases (CVDs) are a global threat to public health, accounting
for almost one‐third of all deaths worldwide. One of the key mechanistic pathways …

Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases

SSM Sofiullah, DD Murugan, SA Muid, WY Seng… - Molecules, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of death worldwide, in both developed
and developing countries. According to the WHO report, the morbidity and mortality caused …

Are endothelial progenitor cells the real solution for cardiovascular diseases? Focus on controversies and perspectives

CR Balistreri, S Buffa, C Pisano, D Lio… - BioMed research …, 2015 - Wiley Online Library
Advanced knowledge in the field of stem cell biology and their ability to provide a cue for
counteracting several diseases are leading numerous researchers to focus their attention on …

The importance of NADPH oxidases and redox signaling in angiogenesis

R Prieto-Bermejo, A Hernández-Hernández - Antioxidants, 2017 - mdpi.com
Eukaryotic cells have to cope with the constant generation of reactive oxygen species
(ROS). Although the excessive production of ROS might be deleterious for cell biology, there …

The role of nitric oxide in renovascular hypertension: from the pathophysiology to the treatment

BP Pereira, GT do Vale, CS Ceron - Naunyn-Schmiedeberg's Archives of …, 2022 - Springer
Renovascular hypertension is one of the most relevant causes of secondary hypertension,
mostly caused by atherosclerotic renovascular stenosis or fibromuscular dysplasia. The …