There is a wealth of new fluorescent reporter technologies for tagging of many cellular and
subcellular processes in vivo. This imposed contrast is now captured with an increasing …

Cardiac optical mapping has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …

Aims The complex architecture of the human atria may create physical substrates for
sustained re-entry to drive atrial fibrillation (AF). The existence of sustained, anatomically …

It has become widely accepted that the most dangerous cardiac arrhythmias are due to
reentrant waves, ie, electrical wave (s) that recirculate repeatedly throughout the tissue at a …

Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

The self-organized dynamics of vortex-like rotating waves, which are also known as scroll
waves, are the basis of the formation of complex spatiotemporal patterns in many excitable …

Heart failure (HF) commonly results in atrial fibrillation (AF) and fibrosis, but how the
distribution of fibrosis impacts AF dynamics has not been studied. HF was induced in sheep …

The heart is a nonlinear biological system that can exhibit complex electrical dynamics,
complete with period-doubling bifurcations and spiral and scroll waves that can lead to …

Background—The foundation for successful arrhythmia ablation is the mapping of electric
propagation to identify underlying mechanisms. In atrial fibrillation (AF), however, mapping …

Objectives: We sought to confirm our hypothesis that the human sinoatrial node (SAN) is
functionally insulated from the surrounding atrial myocardium except for several exit …