Epigenetics of lung cancer: a translational perspective

Á Quintanal-Villalonga, S Molina-Pinelo - Cellular Oncology, 2019 - Springer
Background Lung cancer remains the most common cause of cancer-related death, with a 5-
year survival rate of only 18%. In recent years, the development of targeted pharmacological …

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci

PP Amaral, T Leonardi, N Han, E Viré, DK Gascoigne… - Genome biology, 2018 - Springer
Background The mammalian genome is transcribed into large numbers of long noncoding
RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly …

Lineage factors and differentiation states in lung cancer progression

WKC Cheung, DX Nguyen - Oncogene, 2015 - nature.com
Lung cancer encompasses a heterogeneous group of malignancies. Here we discuss how
the remarkable diversity of major lung cancer subtypes is manifested in their transforming …

Identification of prognostic gene biomarkers in non-small cell lung cancer progression by integrated bioinformatics analysis

P Giannos, KS Kechagias, A Gal - Biology, 2021 - mdpi.com
Simple Summary Non-small cell lung cancer (NSCLC) is a major contributor to cancer
related deaths worldwide. The progression of NSCLC is linked to epithelial-mesenchymal …

Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer

N Yamaguchi, AR Lucena-Araujo, S Nakayama… - Lung cancer, 2014 - Elsevier
Introduction The multitargeted tyrosine kinase inhibitor (TKI) crizotinib is active against ALK
translocated non-small-cell lung cancer (NSCLC); however acquired resistance invariably …

Seven-CpG-based prognostic signature coupled with gene expression predicts survival of oral squamous cell carcinoma

S Shen, G Wang, Q Shi, R Zhang, Y Zhao, Y Wei… - Clinical …, 2017 - Springer
Background DNA methylation has started a recent revolution in genomics biology by
identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma …

A high-concentrate diet provokes inflammatory responses by downregulating Forkhead box protein A2 (FOXA2) through epigenetic modifications in the liver of dairy …

W Xie, Y Xue, H Zhang, Y Wang, M Meng, G Chang… - Gene, 2022 - Elsevier
A high-concentrate diet has been reported to promote an inflammatory response in dairy
cows. The purpose of this study was to clarify the effect of the high-concentrate (HC) diet on …

CD44 promotes breast cancer metastasis through AKT-mediated downregulation of nuclear FOXA2

A Vadhan, MF Hou, P Vijayaraghavan, YC Wu, SCS Hu… - Biomedicines, 2022 - mdpi.com
The primary cause of breast cancer mortality is the metastatic invasion of cancerous stem
cells (CSC). Cluster of differentiation 44 (CD44) is a well-known CSC marker in various …

FOXD1 expression is associated with poor prognosis in non-small cell lung cancer

S Nakayama, K Soejima, H Yasuda, S Yoda… - Anticancer …, 2015 - ar.iiarjournals.org
Aim: Clinical microarray datasets were analyzed to search for new therapeutic targets and
prognostic markers of non-small cell lung cancer (NSCLC). Materials and Methods …

[HTML][HTML] Melatonin suppresses hepatocellular carcinoma progression via lncRNA-CPS1-IT-mediated HIF-1α inactivation

TH Wang, CH Wu, CT Yeh, SC Su, SM Hsia, KH Liang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Melatonin is the primary pineal hormone that relays light/dark cycle information to the
circadian system. It was recently reported to exert intrinsic antitumor activity in various …