Arginine, transsulfuration, and folic acid pathway metabolomics in chronic obstructive pulmonary disease: a systematic review and meta-analysis

A Zinellu, AA Mangoni - Cells, 2023 - mdpi.com
There is an increasing interest in biomarkers of nitric oxide dysregulation and oxidative
stress to guide management and identify new therapeutic targets in patients with chronic …

[HTML][HTML] Circulating arginine metabolites in Alzheimer's disease and vascular dementia: A systematic review and meta-analysis

A Zinellu, S Tommasi, S Sedda, AA Mangoni - Ageing Research Reviews, 2023 - Elsevier
Background Alterations in nitric oxide (NO) synthesis have been reported in Alzheimer's
disease and vascular dementia. However, as the measurement of NO in biological samples …

Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography–Mass …

MG Fleszar, J Wiśniewski, M Krzystek-Korpacka… - Chromatographia, 2018 - Springer
Nitric oxide (NO) is a small molecule involved in the regulation of many physiological
processes. It plays a crucial role in the regulation of nervous system, immune and …

[HTML][HTML] Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro

JA Hulin, S Tommasi, D Elliot, AA Mangoni - Biomedicine & …, 2019 - Elsevier
Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a key enzyme involved in
the metabolism of the endogenous nitric oxide synthase (NOS) inhibitors asymmetric …

A diethylpyrocarbonate-based derivatization method for the LC-MS/MS measurement of plasma arginine and its chemically related metabolites and analogs

S Sotgia, A Zinellu, P Paliogiannis, GA Pinna… - Clinica Chimica …, 2019 - Elsevier
Background Changes in NO metabolism correlate with cardiovascular risk factors and are
associated with endothelial dysfunction. NO availability is regulated by nitric oxide synthase …

Opposing effects of rheumatoid arthritis and low dose prednisolone on arginine metabolomics

A Radhakutty, BL Mangelsdorf, SM Drake, A Rowland… - Atherosclerosis, 2017 - Elsevier
Background and aims The effects of low dose prednisolone on circulating markers of
endothelial function, the arginine metabolites asymmetric dimethyl arginine (ADMA), mono …

A novel mass spectrometry‐based method for simultaneous determination of asymmetric and symmetric dimethylarginine, l‐arginine and l‐citrulline optimized for LC …

J Wiśniewski, MG Fleszar, J Piechowicz… - Biomedical …, 2017 - Wiley Online Library
Nitric oxide (NO) is a regulatory molecule involved in many biological processes. NO is
produced by nitric oxide synthase by conversion of l‐arginine to l‐citrulline. l‐Arginine …

Arginine metabolomics in mood disorders

A Zinellu, S Tommasi, S Sedda, AA Mangoni - Heliyon, 2024 - cell.com
Alterations of nitric oxide (NO) homeostasis have been described in mood disorders.
However, the analytical challenges associated with the direct measurement of NO have …

Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1

S Tommasi, C Zanato, BC Lewis, PC Nair… - Organic & …, 2015 - pubs.rsc.org
Dimethylarginine dimethylaminohydrolase (DDAH) is a key enzyme involved in the
metabolism of asymmetric dimethylarginine (ADMA) and N-monomethyl arginine (NMMA) …

Metabolomic approach to redox and nitrosative reactions in cardiovascular diseases

M Deidda, A Noto, PP Bassareo… - Frontiers in …, 2018 - frontiersin.org
Metabolomics, also referred to as metabonomics, is one of the most recent innovative
technologies in medicine. It offers a direct functional read-out of phenotypes by the …