BACKGROUND The essential amino acid tryptophan is a substrate for the generation of
several bioactive compounds with important physiological roles. Only a small fraction of …

The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and
generates a number of neuroactive metabolites collectively called the kynurenines …

Many patients with cancer suffer from anemia, depression, and an impaired quality of life
(QoL). These patients often also show decreased plasma tryptophan levels and increased …

There is developing interest in the role of the kynurenines in the immune function. A
considerable amount of evidence has accumulated as concerns interactions between the …

The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes
immunosuppression in response to infection or inflammation. Indoleamine 2, 3-dioxygenase …

Over the past years, an increasing amount of evidence has emerged in support of the
kynurenine pathway's (KP) pivotal role in the pathogenesis of several neurodegenerative …

To investigate the role of the Toll‐like receptor (TLR) family in host defense against
Toxoplasma gondii, we infected TLR2‐, TLR4‐and MyD88‐deficient mice with the avirulent …

In a cross sectional study, 19 French and 23 Colombian cases of confirmed active ocular
toxoplasmosis (OT) were evaluated. The objective was to compare clinical, parasitological …

The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in
the activation of the transcription factors STAT3 and STAT6, but it is unclear how these …

ABSTRACT The induction of indoleamine 2, 3-dioxygenase (INDO) expression and the
tryptophan (Trp)-kynurenine (Kyn) metabolic pathway during in vivo infection with …