Genetic architectures of psychiatric disorders: the emerging picture and its implications

PF Sullivan, MJ Daly, M O'donovan - Nature Reviews Genetics, 2012 - nature.com
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …

The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology

OB Smeland, O Frei, AM Dale… - Nature Reviews …, 2020 - nature.com
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

[HTML][HTML] Genetics of schizophrenia: overview of methods, findings and limitations

MG Henriksen, J Nordgaard… - Frontiers in human …, 2017 - frontiersin.org
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular
genetic research has produced novel findings, infusing optimism about discovering the …

Genome‐wide association study of schizophrenia in Ashkenazi Jews

FS Goes, J McGrath, D Avramopoulos… - American Journal of …, 2015 - Wiley Online Library
Schizophrenia is a common, clinically heterogeneous disorder associated with lifelong
morbidity and early mortality. Several genetic variants associated with schizophrenia have …

The role of genetics in the etiology of schizophrenia

PV Gejman, AR Sanders, J Duan - Psychiatric Clinics, 2010 - psych.theclinics.com
This article introduces the reader to the genetics of schizophrenia: its background; the status
of a variety of genetic findings; new developments (which are many since the last review) 1; …

[HTML][HTML] DNA methylation and schizophrenia: current literature and future perspective

T Magwai, KB Shangase, FO Oginga, B Chiliza… - Cells, 2021 - mdpi.com
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

[HTML][HTML] Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia

J Tarabeux, O Kebir, J Gauthier, FF Hamdan… - Translational …, 2011 - nature.com
Pharmacological, genetic and expression studies implicate N-methyl-D-aspartate (NMDA)
receptor hypofunction in schizophrenia (SCZ). Similarly, several lines of evidence suggest …

[HTML][HTML] Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system

AS Cristino, SM Williams, Z Hawi, JY An… - Molecular …, 2014 - nature.com
Many putative genetic factors that confer risk to neurodevelopmental disorders such as
autism spectrum disorders (ASDs) and X-linked intellectual disability (XLID), and to …

Gene–environment interplay in the etiology of psychosis

A Zwicker, EM Denovan-Wright, R Uher - Psychological medicine, 2018 - cambridge.org
Schizophrenia and other types of psychosis incur suffering, high health care costs and loss
of human potential, due to the combination of early onset and poor response to treatment …