Understanding the pathogenesis of abdominal aortic aneurysms
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …
the aortic wall continues to weaken and becomes unable to withstand the forces of the …
Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
Risk of aortic dissection and aortic aneurysm in patients taking oral fluoroquinolone
CC Lee, MG Lee, YS Chen, SH Lee… - JAMA internal …, 2015 - jamanetwork.com
Importance Fluoroquinolones have been associated with collagen degradation, raising
safety concerns related to more serious collagen disorders with use of these antibiotics …
safety concerns related to more serious collagen disorders with use of these antibiotics …
An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
BC Tieu, C Lee, H Sun, W LeJeune… - The Journal of …, 2009 - Am Soc Clin Investig
Vascular inflammation contributes to cardiovascular diseases such as aortic aneurysm and
dissection. However, the precise inflammatory pathways involved have not been clearly …
dissection. However, the precise inflammatory pathways involved have not been clearly …
Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and
environmental risk factors. Together, 6 previously identified risk loci only explain a small …
environmental risk factors. Together, 6 previously identified risk loci only explain a small …
Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II–induced aortic aneurysm
Objective—Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease;
however, the molecular basis underlying the sterile inflammatory response involved in the …
however, the molecular basis underlying the sterile inflammatory response involved in the …
Detection of oral bacteria in cardiovascular specimens
K Nakano, H Nemoto, R Nomura… - Oral microbiology …, 2009 - Wiley Online Library
Background/aims: Oral bacteria, including cariogenic and periodontal pathogens, are
thought to be etiological factors in the development of cardiovascular diseases. To define …
thought to be etiological factors in the development of cardiovascular diseases. To define …
[HTML][HTML] Flt3 signaling-dependent dendritic cells protect against atherosclerosis
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become
macrophages. We looked for these cells in the steady state adult mouse aorta, and …
macrophages. We looked for these cells in the steady state adult mouse aorta, and …
Cytokines in abdominal aortic aneurysm: master regulators with clinical application
OA Puchenkova, VO Soldatov, AE Belykh… - Biomarker …, 2022 - journals.sagepub.com
Abdominal aortic aneurysm (AAA) is a potentially life-threatening disorder with a mostly
asymptomatic course where the abdominal aorta is weakened and bulged. Cytokines play …
asymptomatic course where the abdominal aorta is weakened and bulged. Cytokines play …
Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II− induced abdominal aortic aneurysm in mice
Z Liu, H Luo, L Zhang, Y Huang, B Liu, K Ma… - Circulation …, 2012 - Am Heart Assoc
Rationale: A number of epidemiological studies have suggested an association of
hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies …
hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies …