Understanding the pathogenesis of abdominal aortic aneurysms

H Kuivaniemi, EJ Ryer, JR Elmore… - Expert review of …, 2015 - Taylor & Francis
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …

Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells

G Qian, O Adeyanju, A Olajuyin, X Guo - Life, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …

Risk of aortic dissection and aortic aneurysm in patients taking oral fluoroquinolone

CC Lee, MG Lee, YS Chen, SH Lee… - JAMA internal …, 2015 - jamanetwork.com
Importance Fluoroquinolones have been associated with collagen degradation, raising
safety concerns related to more serious collagen disorders with use of these antibiotics …

An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice

BC Tieu, C Lee, H Sun, W LeJeune… - The Journal of …, 2009 - Am Soc Clin Investig
Vascular inflammation contributes to cardiovascular diseases such as aortic aneurysm and
dissection. However, the precise inflammatory pathways involved have not been clearly …

Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci

GT Jones, G Tromp, H Kuivaniemi… - Circulation …, 2017 - Am Heart Assoc
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and
environmental risk factors. Together, 6 previously identified risk loci only explain a small …

Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II–induced aortic aneurysm

F Usui, K Shirasuna, H Kimura, K Tatsumi… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease;
however, the molecular basis underlying the sterile inflammatory response involved in the …

Detection of oral bacteria in cardiovascular specimens

K Nakano, H Nemoto, R Nomura… - Oral microbiology …, 2009 - Wiley Online Library
Background/aims: Oral bacteria, including cariogenic and periodontal pathogens, are
thought to be etiological factors in the development of cardiovascular diseases. To define …

[HTML][HTML] Flt3 signaling-dependent dendritic cells protect against atherosclerosis

JH Choi, C Cheong, DB Dandamudi, CG Park… - Immunity, 2011 - cell.com
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become
macrophages. We looked for these cells in the steady state adult mouse aorta, and …

Cytokines in abdominal aortic aneurysm: master regulators with clinical application

OA Puchenkova, VO Soldatov, AE Belykh… - Biomarker …, 2022 - journals.sagepub.com
Abdominal aortic aneurysm (AAA) is a potentially life-threatening disorder with a mostly
asymptomatic course where the abdominal aorta is weakened and bulged. Cytokines play …

Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II− induced abdominal aortic aneurysm in mice

Z Liu, H Luo, L Zhang, Y Huang, B Liu, K Ma… - Circulation …, 2012 - Am Heart Assoc
Rationale: A number of epidemiological studies have suggested an association of
hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies …