Since its discovery in 2012, ferroptosis has been well characterized by the accumulation of
lipid peroxides due to the failure of glutathione-dependent antioxidant defenses. It is known …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

A better understanding of the mechanisms through which anticancer drugs exert their effects
is essential to improve combination therapies. While studying how genotoxic stress kills …

Long noncoding RNAs can serve as oncogenes or tumor suppressors in human cancer;
however, their biological functions and underlying mechanism in hepatocarcinogenesis are …

Cancer is a complex disease since it is adaptive in such a way that it can promote
proliferation and invasion by means of an overactive cell cycle and in turn cellular division …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

Emergence of castration-resistant metastatic prostate cancer is due to activation of survival
pathways, including apoptosis suppression and anoikis resistance, and increased …

Acute myocardial infarction remains the leading cause of death in humans. Timely
restoration of blood perfusion to ischemic myocardium remains the most effective strategy in …

The TNF-related apoptosis-inducing ligand, TRAIL, has been shown to selectively kill
tumour cells. This property has made TRAIL and agonistic antibodies against its death …

Ferroptosis is a type of programmed cell death that depends on iron and is characterized by
the accumulation of lipid peroxides. In the present study, we investigated the nature of the …