Preeclampsia is a pregnancy-specific complication that is associated with an increased
postpartum risk of cardiovascular disease (CVD) in both women and their offspring, although …

The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …

Proper placental development in early pregnancy ensures a positive outcome later on. The
developmental relationship between the placenta and embryonic organs, such as the heart …

Successful pregnancy relies directly on the placenta's complex, dynamic, gene-regulatory
networks. Disruption of this vast collection of intercellular and intracellular programs leads to …

Decidualisation of the endometrium is a key event in early pregnancy, which enables
embryo implantation. Importantly, the molecular processes impairing decidualisation in …

The placenta becomes one of the most diversified organs during placental mammal
radiation. The main in vitro model for studying mouse trophoblast development is the 2D …

Immune dysfunction in early pregnancy including overactivation of cytotoxic CD16+ NK cells
and proinflammatory M1 macrophages at the maternal–fetal interface interferes with …

The maternal-fetal environment, controlled and modulated by the placenta, plays a critical
role in the development and well-being of the fetus, with long-term impact through …

The placenta and fetal heart undergo development concurrently during early pregnancy,
and, while human studies have reported associations between placental abnormalities and …

The impact of placental dysfunction and placental injury on the fetus and newborn infant has
become a topic of growing interest in neonatal disease research. However, the use of …