Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble
purines which prompted biological investigations to assess their potential therapeutic …

1. INTRODUCTION Nitrogen-containing heterocycles are widely distributed in nature and
essential for life, playing a vital role in the metabolism of all living cells. Among the many …

Pyrazolo [3, 4-d] pyrimidines have become of significant interest for the medicinal chemistry
community as a privileged scaffold for the development of kinase inhibitors to treat a range …

Chalcones belong to the flavonoid family which constitutes one of the major classes of
naturally occurring oxygen heterocyclic compounds. The α, β-unsaturated carbonyl system …

The LIM kinases 1 and 2 (LIMK1 and LIMK2) are dual specificity (serine/threonine and
tyrosine) kinases. Although they show significant structural similarity, LIMK1 and LIMK2 …

Abstract A novel series of 4, 6-disubstituted pyrazolo [3, 4-d] pyrimidines (7–43) bearing
various anilines at C-4 position and thiophenethyl or thiopentane moieties at C-6 position …

Pyrazole is a versatile lead compound to design potent bioactive molecules for drug
discovery and development, particularly in cancer therapy. The aim of this review is to …

The synthesis of a series of certain polymethoxy chalcones and some derived pyrazole,
pyrimidine, and thiazolopyrimidine ring structures is reported. Eleven compounds 4, 6, 9, 11 …

The synthesis of two novel series of 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazoles linked to
either polysubstituted 1H-pyrazole counterparts through a carbonyl bridge, or to some …

A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo [3, 4-d] pyrimidine
scaffold was previously reported by us and proved to be active against several tumor cell …