ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Abstract Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …

Cellular stress responses are mediated through a series of regulatory processes that occur
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1), also referred to as ADP-
ribosyltransferase Diphtheria toxin-like 1 (ARTD1), is an abundant nuclear protein that plays …

Poly (ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer
negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide …

Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …

Although discovered long ago, posttranslational phosphorylation of histones has been in the
spotlight only recently. Information is accumulating almost daily on phosphorylation of …

RNA polymerase II (Pol II) must break the nucleosomal barrier to gain access to DNA and
transcribe genes efficiently. New single-molecule techniques have elucidated many …