Gut-derived protein-bound uremic toxins

AL Graboski, MR Redinbo - Toxins, 2020 - mdpi.com
Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of
the fastest growing global causes of mortality. When glomerular filtration rate begins to fall …

Sarcopenia in chronic kidney disease: factors, mechanisms, and therapeutic interventions

H Watanabe, Y Enoki, T Maruyama - Biological and Pharmaceutical …, 2019 - jstage.jst.go.jp
Chronic kidney disease (CKD), a chronic catabolic condition, is characterized by muscle
wasting and decreased muscle endurance. Many insights into the molecular mechanisms of …

The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction

KJ Prentice, L Luu, EM Allister, Y Liu, LS Jun… - Cell metabolism, 2014 - cell.com
Gestational diabetes (GDM) results from failure of the β cells to adapt to increased metabolic
demands; however, the cause of GDM and the extremely high rate of progression to type 2 …

Cerebro-renal interactions: impact of uremic toxins on cognitive function

K Watanabe, T Watanabe, M Nakayama - Neurotoxicology, 2014 - Elsevier
Cognitive impairment (CI) associated with chronic kidney disease (CKD) has received
attention as an important problem in recent years. Causes of CI with CKD are multifactorial …

Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK‐3β/Nrf2 Signaling Pathway and Inhibiting the NF‐κB Signaling Pathway in …

H Zhang, J Wang, Y Wang, C Gao, Y Gu… - Oxidative Medicine …, 2019 - Wiley Online Library
Salvianolic acid A (SAA) is a bioactive polyphenol extracted from Salviae miltiorrhizae
Bunge, which possesses a variety of pharmacological activities. In our previous study, we …

Furan fatty acids–Beneficial or harmful to health?

L Xu, AJ Sinclair, M Faiza, D Li, X Han, H Yin… - Progress in Lipid …, 2017 - Elsevier
Furan fatty acids are found in plants, algae, and fish, and reported to have some positive
health benefits, including anti-oxidant and anti-inflammatory activities, and inhibition of non …

Food preference patterns in a UK twin cohort

T Pallister, M Sharafi, G Lachance, N Pirastu… - Twin Research and …, 2015 - cambridge.org
Food liking-disliking patterns may strongly influence food choices and health. Here we
assess:(1) whether food preference patterns are genetic/environmentally driven; and (2) the …

[HTML][HTML] The association between TMAO, CMPF, and clinical outcomes in advanced chronic kidney disease: results from the European QUALity (EQUAL) Study

L Dai, ZA Massy, P Stenvinkel, NC Chesnaye… - The American Journal of …, 2022 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO), a metabolite from red meat and
fish consumption, plays a role in promoting cardiovascular events. However, data regarding …

Plasma metabolomic profiles in different stages of CKD

VO Shah, RR Townsend, HI Feldman… - Clinical Journal of the …, 2013 - journals.lww.com
Results Comparison of stage 3/stage 2 identified 62 metabolites that differed (P≤ 0.05), with
39 higher and 23 lower in stage 3 compared with stage 2; comparisons of stage 4/stage 2 …

The interplay between uremic toxins and albumin, membrane transporters and drug interaction

RS Cunha, CAB Azevedo, CA Falconi, FF Ruiz… - Toxins, 2022 - mdpi.com
Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to
the progression of chronic kidney disease (CKD). These toxins are associated with kidney …