Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …

Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types
which are involved in a great variety of cellular processes. Reversible acetylation on the ϵ …

Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …

Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

The emerging view of Nε-lysine acetylation in eukaryotes is of a relatively abundant post-
translational modification (PTM) that has a major impact on the function, structure, stability …