Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti‐Inflammatory, and Anticancer Properties

M Ozkur, N Benlier, I Takan, C Vasileiou… - Oxidative medicine …, 2022 - Wiley Online Library
The world's population is ageing at an accelerated pace. Ageing is a natural, physiological
but highly complex and multifactorial process that all species in the Tree of Life experience …

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

PD Fransquet, J Wrigglesworth, RL Woods, ME Ernst… - Clinical …, 2019 - Springer
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …

[HTML][HTML] Biomarkers of aging for the identification and evaluation of longevity interventions

M Moqri, C Herzog, JR Poganik, J Justice, DW Belsky… - Cell, 2023 - cell.com
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …

Circulating exosomal miRNA as diagnostic biomarkers of neurodegenerative diseases

L Wang, L Zhang - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases (NDDs) are a group of diseases caused by chronic and
progressive degeneration of neural tissue. The main pathological manifestations are …

Impact of Maillard reaction products on nutrition and health: Current knowledge and need to understand their fate in the human digestive system

N ALjahdali, F Carbonero - Critical Reviews in Food Science and …, 2019 - Taylor & Francis
ABSTRACT The Maillard Reaction (MR) is a non-enzymatic chemical reaction which results
in the linkage between the amino group of amino acids and the carbonyl group of reduced …

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

PA Dugué, JK Bassett, JHE Joo… - … journal of cancer, 2018 - Wiley Online Library
The association between aging and cancer is complex. Recent studies have developed
measures of biological aging based on DNA methylation and called them “age …

[HTML][HTML] Molecular and phenotypic biomarkers of aging

X Xia, W Chen, J McDermott, JDJ Han - F1000Research, 2017 - ncbi.nlm.nih.gov
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …