The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Trypanosoma cruzi acute infections often go unperceived, but one third of chronically
infected individuals die of Chagas disease, showing diverse manifestations affecting the …

James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …

Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Three common systemic human fungal pathogens—Cryptococcus neoformans, Candida
albicans and Aspergillus fumigatus—have retained all the machinery to engage in sexual …

Background Trypanosoma cruzi, the causative agent of Chagas disease, displays significant
genetic variability revealed by six Discrete Typing Units (TcI-TcVI). In this pathology, oral …

Background Mitochondrial DNA is a valuable taxonomic marker due to its relatively fast rate
of evolution. In Trypanosoma cruzi, the causative agent of Chagas disease, the …

Background Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans
and other wild and domestic mammals across Central and South America. It does not cause …

RNA editing in kinetoplastid protozoa is a post-transcriptional process of uridine insertion or
deletion in mitochondrial mRNAs. The process involves two RNA species, the pre-edited …

Background The Trypanosoma cruzi genome was sequenced from a hybrid strain (CL
Brener). However, high allelic variation and the repetitive nature of the genome have …