Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

In patients with renal diseases characterized by proteinuria, the initial insult to the kidney is
usually followed by a progressive decline in the glomerular filtration rate. This decline has …

The possibility that proteinuria may accelerate kidney disease progression to end-stage
renal failure has received support from the results of increasing numbers of experimental …

Background In the present study, we aimed to determine the frequency of a significant
reduction in urinary albumin excretion and factors affecting such reduction in patients with …

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral
circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal …

All progressive renal diseases are the consequence of a process of destructive fibrosis. This
review will focus on tubulointerstitial fibrosis, the pathophysiology of which will be divided …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Pathophysiology of proteinuria. Proteinuria is consequence of two mechanisms: the
abnormal transglomerular passage of proteins due to increased permeability of glomerular …

Chronic kidney diseases share common pathogenic mechanisms that, independently from
the initial injury, lead to glomerular hyperfiltration, proteinuria, and progressive renal …

Albumin is the most abundant plasmaprotein serving multiple functions as a carrier of
metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by …