Engineering hydrogels for affinity-based release of therapeutic proteins

CJ Teal, SP Lu, MS Shoichet - Chemistry of Materials, 2024 - ACS Publications
Therapeutic proteins can treat a myriad of diseases; however, their effectiveness is limited
by short half-lives. Controlled release systems are advantageous because they prolong the …

Conserved Protein–Polymer Interactions across Structurally Diverse Polymers Underlie Alterations to Protein Thermal Unfolding

A Pritzlaff, G Ferré, E Dargassies, CO Williams… - ACS Central …, 2023 - ACS Publications
Protein–polymer conjugates are widely used in many clinical and industrial applications, but
lack of experimental data relating protein–polymer interactions to improved protein stability …

Investigating the impact of polymer length, attachment site, and charge on enzymatic activity and stability of cellulase

TA Wright, C Bennett, MR Johnson… - …, 2022 - ACS Publications
The thermophilic cellulase Cel5a from Fervidobacterium nodosum (Fn Cel5a) was
conjugated with neutral, cationic, and anionic polymers of increasing molecular weights. The …

Reproducible and controlled peptide functionalization of polymeric nanoparticles

I Chandrasiri, Y Liu, E Adjei-Sowah, B Xiao… - Frontiers in …, 2022 - frontiersin.org
Polymeric nanoparticles containing multiple amines and carboxylates have been frequently
used in drug delivery research. Reproducible and controlled conjugation among these …

Dual Function of β‐Hydroxy Dithiocinnamic Esters: RAFT Agent and Ligand for Metal Complexation

MK Farh, FV Gruschwitz, N Ziegenbalg… - Macromolecular …, 2022 - Wiley Online Library
The reversible addition‐fragmentation chain‐transfer (RAFT) process has become a
versatile tool for the preparation of defined polymers tolerating a large variety of functional …

Synthesis and Evaluation of Clinically Translatable Targeted Microbubbles Using a Microfluidic Device for In Vivo Ultrasound Molecular Imaging

R Bam, A Natarajan, F Tabesh, R Paulmurugan… - International Journal of …, 2023 - mdpi.com
The main aim of this study is to synthesize contrast microbubbles (MB) functionalized with
engineered protein ligands using a microfluidic device to target breast cancer specific …

Traceless pH-Sensitive Antibody Conjugation Inspired by Citraconic Anhydride

D Melodia, Z Di Pietro, C Cao, MH Stenzel… - …, 2022 - ACS Publications
We introduce a pH-sensitive amide bond, inspired by citraconic anhydride, for the reversible
conjugation of polymers to the lysine residues of proteins and antibodies. The pH sensitivity …

Polymer modification of SARS-CoV-2 spike protein impacts its ability to bind key receptor

MS Rahman, NDA Watuthanthrige… - European Polymer …, 2023 - Elsevier
The global spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) has
caused the loss of many human lives and severe economic losses. SARS-CoV-2 mediates …

[PDF][PDF] Dual Function of 𝜷-Hydroxy Dithiocinnamic Esters: RAFT Agent and Ligand for Metal Complexation

MK Farh, FV Gruschwitz, N Ziegenbalg, H Abul-Futouh… - 2022 - core.ac.uk
The reversible addition-fragmentation chain-transfer (RAFT) process has become a versatile
tool for the preparation of defined polymers tolerating a large variety of functional groups …

[PDF][PDF] Covalent Post-Assembly Modification of Metal-Organic Capsules

I Jahović - 2022 - repository.cam.ac.uk
Self-assembled molecular containers have been used for a range of applications, including
molecular sensing, catalysis, and chemical separations. Post-assembly modification of these …