[HTML][HTML] Unique Properties of Apicomplexan Mitochondria

IM Lamb, IC Okoye, MW Mather… - Annual review of …, 2023 - annualreviews.org
Apicomplexan parasites constitute more than 6,000 species infecting a wide range of hosts.
These include important pathogens such as those causing malaria and toxoplasmosis. Their …

Massive invasion of organellar DNA drives nuclear genome evolution in Toxoplasma

S Namasivayam, C Sun, AB Bah… - Proceedings of the …, 2023 - National Acad Sciences
Toxoplasma gondii is a zoonotic protist pathogen that infects up to one third of the human
population. This apicomplexan parasite contains three genome sequences: nuclear (65 Mb); …

[HTML][HTML] Mitochondrial Cytochrome bc1 Complex as Validated Drug Target: A Structural Perspective

L Esser, D Xia - Tropical Medicine and Infectious Disease, 2024 - mdpi.com
Mitochondrial respiratory chain Complex III, also known as cytochrome bc 1 complex or cyt
bc 1, is a validated target not only for antibiotics but also for pesticides and anti-parasitic …

[HTML][HTML] Mitochondrial and apicoplast genome copy abundances of haemosporidian parasites are explained by host species and parasitic lineage

T Brandler, N Chakarov - Frontiers in Ecology and Evolution, 2024 - frontiersin.org
Endosymbiotic organelles, such as mitochondria and plastids, contain own remnant
genomes (nucleoids), whose variable abundance in cells may be adaptive to the …

Small RNAs from mitochondrial genome recombination sites are incorporated into T. gondii mitoribosomes

S Tetzlaff, A Hillebrand, N Drakoulis, Z Gluhic… - Elife, 2024 - elifesciences.org
The mitochondrial genomes of apicomplexans comprise merely three protein-coding genes,
alongside a set of thirty to forty genes encoding small RNAs (sRNAs), many of which exhibit …

[HTML][HTML] Complete mitochondrial genome analyses confirm that bat Polychromophilus and ungulate Plasmodium constitute a distinct clade independent of other …

J Poofery, T Ngamprasertwong, D Narapakdeesakul… - Scientific Reports, 2023 - nature.com
In recent phylogenetic studies, bat Polychromophilus and ungulate Plasmodium, two
relatively understudied haemosporidian parasites within the Apicomplexa phylum, have …

Mitochondrial Genomes in Perkinsus Decode Conserved Frameshifts in All Genes

SG Gornik, V Flores, F Reinhardt, L Erber… - Molecular biology …, 2022 - academic.oup.com
Mitochondrial genomes of apicomplexans, dinoflagellates, and chrompodellids that
collectively make up the Myzozoa, encode only three proteins (Cytochrome b [COB] …

A century of mitochondrial research, 1922–2022

HT Jacobs - The Enzymes, 2023 - trepo.tuni.fi
Although recognized earlier as subcellular entities by microscopists, mitochondria have
been the subject of functional studies since 1922, when their biochemical similarities with …

[HTML][HTML] Parallel functional reduction in the mitochondria of apicomplexan parasites

PJ Keeling, M Mtawali, M Trznadel… - European Journal of …, 2024 - Elsevier
Extreme functional reduction of mitochondria has taken place in parallel in many distantly
related lineages of eukaryotes, leading to a number of recurring metabolic states with …

A gene-rich mitochondrion with a unique ancestral protein transport system

D Moreira, J Blaz, E Kim, L Eme - bioRxiv, 2024 - biorxiv.org
Mitochondria originated from an ancient endosymbiotic event involving an
alphaproteobacterium. Over time, these organelles reduced their gene content massively …