Retinoblastoma management remains complex, requiring individualized treatment based on
International Classification of Retinoblastoma (ICRB) staging, germline mutation status …

Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in
almost all cases, together with other genetic/epigenetic changes culminating in the …

Abstract Intra-arterial chemotherapy (IAC), also known as superselective ophthalmic artery
chemotherapy or chemosurgery, is currently widely accepted as one of the primary treatment …

Retinoblastoma is the most common primary intraocular malignancy of childhood. It typically
presents with leukocoria or strabismus. In later stages of the disease, the child may exhibit …

Purpose: Cancer stem cells (CSCs) are known to contribute to tumor relapses by virtue of
their chemoresistance. With the knowledge that nanoformulations can overcome drug …

Purpose: To investigate on the safety and efficacy of intravitreous chemotherapy for
retinoblastoma seeding in a relatively large cohort and provide information on the necessary …

With the development of RNA modification research, the importance of N6-methyladenosine
(m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and …

Purpose: To compare outcomes of intra-arterial chemotherapy for retinoblastoma as primary
therapy before (Era I) and during (Era II) the intravitreal chemotherapy era. Methods: In this …

Background Retinoblastoma is the most common primary intraocular malignancy in children.
The management of retinoblastoma is complex and depends on several factors. Methods …

In this review we discuss several recent concepts regarding retinoblastoma control and its
impact. In a cohort of 482 patients with solitary unilateral retinoblastoma revealed germline …