Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Importance Systemic amyloidosis from transthyretin (ATTR) protein is the most common type
of amyloidosis that causes cardiomyopathy. Observations Transthyretin (TTR) protein …

Background Transthyretin amyloid cardiomyopathy is characterized by the deposition of
misfolded monomeric transthyretin (TTR) in the heart. Acoramidis is a high-affinity TTR …

Background Transthyretin amyloid (ATTR) cardiomyopathy is a progressive and fatal
disease caused by misfolded transthyretin. Despite advances in slowing disease …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

Aim The value of disease‐modifying therapies (such as tafamidis) in patients with
transthyretin amyloid cardiomyopathy (ATTR‐CM) and severe heart failure symptoms has …

These guidelines form an update of the BSE guideline protocol for the assessment of
restrictive cardiomyopathy (Knight et al. in Echo Res Prac, 2013). Since the original …

Restrictive cardiomyopathy (RCM) is a heterogeneous group of diseases characterized by
restrictive left ventricular pathophysiology, ie a rapid rise in ventricular pressure with only …

Importance The population prevalence of cardiac transthyretin amyloidosis (ATTR) caused
by pathogenic variation in theTTRgene (vATTR) is unknown. Objective To estimate the …

Importance Individual cohort studies concur that the amyloidogenic V142I variant of the
transthyretin (TTR) gene, present in 3% to 4% of US Black individuals, increases heart …