Elimination of tissue viral reservoirs is likely the key to generation of an effective HIV cure.
Exciting studies have come out recently that reveal crucial insights into topics ranging from …

Understanding the earliest immune responses following HIV infection is critical to inform
future vaccines and therapeutics. Here, we review recent prospective human studies in at …

The role of NK cells against HIV-1 infections remains to be elucidated in vivo. While
humanized mouse models potentially could be used to directly evaluate human NK cell …

Antiretroviral therapy controls HIV replication but does not eliminate the virus from the
infected host. The persistence of a small pool of cells harboring integrated and replication …

Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has become a heavy burden of disease and an important public health problem …

The rebound-competent viral reservoir, composed of a virus that is able to persist during
antiretroviral therapy (ART) and mediate reactivation of systemic viral replication and …

Identifying immune cells and anatomical tissues that contribute to the establishment of viral
reservoirs is of central importance in HIV-1 cure research. Herein, we used rhesus …

Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) continues to
cause new pediatric cases of infection through breastfeeding, a setting where it is not always …

Like other chronic viral infections, HIV-1 persistence inhibits the development of antigen-
specific memory T-cells, resulting in the exhaustion of the immune response and chronic …

HIV infection requires lifelong antiretroviral therapy (ART) to control disease progression.
Although ART has greatly extended the life expectancy of persons living with HIV (PWH) …