Rodent models in neuroscience research: is it a rat race?

B Ellenbroek, J Youn - Disease models & mechanisms, 2016 - journals.biologists.com
Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used
models in biomedical research for many years. A notable shift has taken place over the last …

Do different types of stress differentially alter behavioural and neurobiological outcomes associated with depression in rodent models? A systematic review

A Du Preez, J Eum, I Eiben, P Eiben… - Frontiers in …, 2021 - Elsevier
Cataloguing the effects of different types of stress on behaviour and physiology in rodent
models has not been comprehensively attempted. Here, we systematically review whether …

High-yield methods for accurate two-alternative visual psychophysics in head-fixed mice

CP Burgess, A Lak, NA Steinmetz, P Zatka-Haas… - Cell reports, 2017 - cell.com
Research in neuroscience increasingly relies on the mouse, a mammalian species that
affords unparalleled genetic tractability and brain atlases. Here, we introduce high-yield …

An accumulation-of-evidence task using visual pulses for mice navigating in virtual reality

L Pinto, SA Koay, B Engelhard, AM Yoon… - Frontiers in behavioral …, 2018 - frontiersin.org
The gradual accumulation of sensory evidence is a crucial component of perceptual
decision making, but its neural mechanisms are still poorly understood. Given the wide …

Designing animal-friendly behavioral tests for neuroscience research: the importance of an ethological approach

R d'Isa, R Gerlai - Frontiers in Behavioral Neuroscience, 2023 - frontiersin.org
Behavioral tests have three key elements:(1) a motivating factor (what motivates the animal
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …

Sensory-to-category transformation via dynamic reorganization of ensemble structures in mouse auditory cortex

Y Xin, L Zhong, Y Zhang, T Zhou, J Pan, N Xu - Neuron, 2019 - cell.com
The ability to group physical stimuli into behaviorally relevant categories is fundamental to
perception and cognition. Despite a large body of work on stimulus categorization at the …

Novelty detection in an auditory oddball task on freely moving rats

L Quintela-Vega, CJ Morado-Díaz, G Terreros… - Communications …, 2023 - nature.com
The relative importance or saliency of sensory inputs depend on the animal's environmental
context and the behavioural responses to these same inputs can vary over time. Here we …

Magnetic eye tracking in mice

HL Payne, JL Raymond - elife, 2017 - elifesciences.org
Eye movements provide insights about a wide range of brain functions, from sensorimotor
integration to cognition; hence, the measurement of eye movements is an important tool in …

Stable representation of sounds in the posterior striatum during flexible auditory decisions

L Guo, WI Walker, ND Ponvert, PL Penix… - Nature …, 2018 - nature.com
The neuronal pathways that link sounds to rewarded actions remain elusive. For instance, it
is unclear whether neurons in the posterior tail of the dorsal striatum (which receive direct …

[HTML][HTML] From innate to instructed: A new look at perceptual decision-making

LT Oesch, MB Ryan, AK Churchland - Current Opinion in Neurobiology, 2024 - Elsevier
Understanding how subjects perceive sensory stimuli in their environment and use this
information to guide appropriate actions is a major challenge in neuroscience. To study …