Personalizing direct oral anticoagulant therapy for a diverse population: role of race, kidney function, drug interactions, and pharmacogenetics

LE Thompson, BH Davis, R Narayan… - Clinical …, 2023 - Wiley Online Library
Oral anticoagulants (OACs) are commonly used to reduce the risk of venous
thromboembolism and the risk of stroke in patients with atrial fibrillation. Endorsed by the …

Pharmacogenomics of drugs used to treat brain disorders

R Cacabelos - Expert Review of Precision Medicine and Drug …, 2020 - Taylor & Francis
ABSTRACT Introduction Neuropsychiatric disorders (NPDs)(neurodevelopmental, mental,
neurodegenerative, neurotoxic, complex disorders) are the third major problem of health in …

Toward Genetic Testing of Rivaroxaban? Insights from a Systematic Review on the Role of Genetic Polymorphism in Rivaroxaban Therapy

Y Ma, Z Song, X Li, D Jiang, R Zhao, Z Yi - Clinical Pharmacokinetics, 2024 - Springer
Background Investigations into the rivaroxaban response from the perspective of genetic
variation have been relatively recent and wide in scope, whereas there is no consensus on …

Platelet function testing in atrial fibrillation patients undergoing percutaneous coronary intervention

I Lianos, C Varlamos, DR Benetou, C Mantis… - Journal of Thrombosis …, 2023 - Springer
Platelet function testing (PFT) could be a useful clinical tool to guide individualized
antithrombotic treatment in patients with atrial fibrillation (AF) undergoing percutaneous …

[HTML][HTML] Management of antithrombotic therapy in patients with atrial fibrillation and acute coronary syndromes

C Pop, D Țînț, A Petris - Reviews in Cardiovascular Medicine, 2021 - imrpress.com
If atrial fibrillation (AF) and acute coronary syndrome (ACS) coexist, they should be treated
with combined antithrombotic therapy. To reduce the risk of bleeding while maintaining the …

Effect of ABCB1 gene variants on rivaroxaban pharmacokinetic and hemorrhage events occurring in patients with non‐valvular atrial fibrillation

D Zhang, W Qin, W Du, X Wang… - … & Drug Disposition, 2022 - Wiley Online Library
Hemorrhage events occur most frequently in anticoagulant therapy for non‐valvular atrial
fibrillation (NVAF). Rivaroxaban is used widely for routine anticoagulation care. Genetic …

Selection of miRNAs for clopidogrel resistance prediction

E Rytkin, KB Mirzaev, IV Bure, DA Sychev - Meta Gene, 2020 - Elsevier
Aims This letter to the editor features a selection of possible miRNAs to be included into
further development of smart diagnostic systems for clopidogrel resistance testing. Materials …

Effect of Genotype on the Pharmacokinetics and Bleeding Events of Direct Oral Anticoagulants: A Systematic Review and Meta‐analysis

J Shi, T Wu, S Wu, X Chen, Q Ye… - The Journal of Clinical …, 2023 - Wiley Online Library
This meta‐analysis aimed to investigate the effect of the genotype on the pharmacokinetics
and bleeding events of direct oral anticoagulants (DOACs) and comprehensively searched …

MicroRNAs as novel biomarkers for rivaroxaban therapeutic drug monitoring

E Rytkin, IV Bure, PO Bochkov… - Drug metabolism and …, 2022 - degruyter.com
Objectives The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential
biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation …

Pharmacogenomics in Cardiovascular Diseases

A Kekic - Pharmacogenomics in Clinical Practice, 2024 - Springer
Pharmacogenomics has a potential to improve and individualize treatment of cardiovascular
diseases. In the past couple of decades, strong evidence emerged to inform PGx guided …