Corneal diseases are among the primary causes of blindness and vision loss worldwide.
However, the pathogenesis of corneal diseases remains elusive, and diagnostic and …

Background Currently, most inherited retinal diseases lack curative interventions, and
available treatment modalities are constrained to symptomatic approaches. Retinal organoid …

Reactive oxygen species (ROS) within the retina play a key role in maintaining function and
cell survival. However, excessive ROS can lead to oxidative stress, inducing dysregulation …

Combined removal of Crb1 and Crb2 from the developing optic vesicle evokes cellular and
laminar disorganization by disrupting the apical cell-cell adhesion in developing retinal …

Mutations in the CRB1 gene are associated with a diverse spectrum of retinopathies with
phenotypic variability causing severe visual impairment. The CRB1 gene has a role in …

The CRB1 gene plays a role in retinal development and its maintenance. When disrupted, it
gives a range of phenotypes such as early-onset severe retinal dystrophy/Leber congenital …

Purpose: Mutations affecting the CRB1 gene can result in a range of retinal phenotypes,
including early onset severe retinal dystrophy/Leber congenital amaurosis (EOSRD/LCA) …