Lipid droplet biogenesis and functions in health and disease

A Zadoorian, X Du, H Yang - Nature Reviews Endocrinology, 2023 - nature.com
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Dynamics and functions of lipid droplets

JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

The ménage à trois of autophagy, lipid droplets and liver disease

Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis

L Enkler, V Szentgyörgyi, M Pennauer… - Nature Cell …, 2023 - nature.com
Lipid mobilization through fatty acid β-oxidation is a central process essential for energy
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …

[HTML][HTML] The biogenesis of lipid droplets: lipids take center stage

M Gao, X Huang, BL Song, H Yang - Progress in lipid research, 2019 - Elsevier
Lipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …

Lipid droplet and peroxisome biogenesis occur at the same ER subdomains

AS Joshi, B Nebenfuehr, V Choudhary… - Nature …, 2018 - nature.com
Nascent lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) membrane
but it is not known how sites of biogenesis are determined. We previously identified ER …

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

YA Klug, JC Deme, RA Corey, MF Renne… - Nature …, 2021 - nature.com
Lipid droplets (LDs) are universal lipid storage organelles with a core of neutral lipids, such
as triacylglycerols, surrounded by a phospholipid monolayer. This unique architecture is …

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

S Wang, FZ Idrissi, M Hermansson, A Grippa… - Nature …, 2018 - nature.com
Lipid droplets (LDs) and peroxisomes are ubiquitous organelles with central roles in
eukaryotic cells. Although the mechanisms involved in biogenesis of these organelles …

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

V Zoni, R Khaddaj, I Lukmantara… - Proceedings of the …, 2021 - National Acad Sciences
Lipid droplets (LDs) are intracellular organelles responsible for lipid storage, and they
emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly …