Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
Dynamics and functions of lipid droplets
JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
The ménage à trois of autophagy, lipid droplets and liver disease
Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …
building blocks that are indispensable for liver functions. Energy deficiencies are …
Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis
L Enkler, V Szentgyörgyi, M Pennauer… - Nature Cell …, 2023 - nature.com
Lipid mobilization through fatty acid β-oxidation is a central process essential for energy
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …
[HTML][HTML] The biogenesis of lipid droplets: lipids take center stage
Lipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …
Lipid droplet and peroxisome biogenesis occur at the same ER subdomains
AS Joshi, B Nebenfuehr, V Choudhary… - Nature …, 2018 - nature.com
Nascent lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) membrane
but it is not known how sites of biogenesis are determined. We previously identified ER …
but it is not known how sites of biogenesis are determined. We previously identified ER …
Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
Lipid droplets (LDs) are universal lipid storage organelles with a core of neutral lipids, such
as triacylglycerols, surrounded by a phospholipid monolayer. This unique architecture is …
as triacylglycerols, surrounded by a phospholipid monolayer. This unique architecture is …
Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum
S Wang, FZ Idrissi, M Hermansson, A Grippa… - Nature …, 2018 - nature.com
Lipid droplets (LDs) and peroxisomes are ubiquitous organelles with central roles in
eukaryotic cells. Although the mechanisms involved in biogenesis of these organelles …
eukaryotic cells. Although the mechanisms involved in biogenesis of these organelles …
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …
Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure
V Zoni, R Khaddaj, I Lukmantara… - Proceedings of the …, 2021 - National Acad Sciences
Lipid droplets (LDs) are intracellular organelles responsible for lipid storage, and they
emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly …
emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly …