The pharmacology of second-generation chimeric antigen receptors
SJC Van Der Stegen, M Hamieh… - Nature reviews Drug …, 2015 - nature.com
Second-generation chimeric antigen receptors (CARs) retarget and reprogramme T cells to
augment their antitumour efficacy. The combined activating and co-stimulatory domains …
augment their antitumour efficacy. The combined activating and co-stimulatory domains …
[HTML][HTML] TRAF molecules in cell signaling and in human diseases
P Xie - Journal of molecular signaling, 2013 - Springer
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …
ELM—the Eukaryotic Linear Motif resource—2024 update
M Kumar, S Michael, J Alvarado-Valverde… - Nucleic acids …, 2024 - academic.oup.com
Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …
modular eukaryotic proteins. They are also the most abundant, especially when considering …
Th9 cells represent a unique subset of CD4+ T cells endowed with the ability to eradicate advanced tumors
The antitumor effector T helper 1 (Th1) and Th17 cells represent two T cell paradigms: short-
lived cytolytic Th1 cells and" stem cell-like" memory Th17 cells. We report that Th9 cells …
lived cytolytic Th1 cells and" stem cell-like" memory Th17 cells. We report that Th9 cells …
OX40 signaling favors the induction of TH9 cells and airway inflammation
X Xiao, S Balasubramanian, W Liu, X Chu, H Wang… - Nature …, 2012 - nature.com
The mechanisms that regulate the TH9 subset of helper T cells and diseases mediated by
TH9 cells remain poorly defined. Here we found that the costimulatory receptor OX40 was a …
TH9 cells remain poorly defined. Here we found that the costimulatory receptor OX40 was a …
Potential mechanisms and applications of statins on osteogenesis: Current modalities, conflicts and future directions
Statins are known for their beneficial effects on cardiovascular diseases. Besides the lipid-
lowering properties, statins exert their anabolic effects on the bone by differentiating …
lowering properties, statins exert their anabolic effects on the bone by differentiating …
Fine-tuning of dendritic cell biology by the TNF superfamily
LS Deluca, JL Gommerman - Nature Reviews Immunology, 2012 - nature.com
Members of the tumour necrosis factor (TNF) superfamily have been implicated in a wide
range of biological functions, and their expression by cells of the immune system makes …
range of biological functions, and their expression by cells of the immune system makes …
[HTML][HTML] Intracellular signaling pathways in rheumatoid arthritis
CJ Malemud - Journal of clinical & cellular immunology, 2013 - ncbi.nlm.nih.gov
Dysfunctional intracellular signaling involving deregulated activation of the Janus
Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) and “cross-talk” …
Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) and “cross-talk” …
TRAF molecules in inflammation and inflammatory diseases
Abstract Purpose of Review This review presents an overview of the current knowledge of
tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) molecules in inflammation …
tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) molecules in inflammation …
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation
BB Chen, TA Coon, JR Glasser, BJ McVerry… - Nature …, 2013 - nature.com
Uncontrolled activation of tumor necrosis factor receptor–associated factor (TRAF) proteins
may result in profound tissue injury by linking surface signals to cytokine release. Here we …
may result in profound tissue injury by linking surface signals to cytokine release. Here we …