Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time.
One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton …

The tooth root is an integral, functionally important part of our dentition. The formation of a
functional root depends on epithelial-mesenchymal interactions and integration of the root …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

The identification of subtype-specific translocations has revolutionized the diagnostics of
sarcoma and has provided new insight into oncogenesis. We used RNA-seq to investigate …

Human bone marrow mesenchymal stem/stromal cells (MSCs) are multipotent progenitor
cells with multilineage differentiation potentials including osteogenesis and adipogenesis …

Mesenchymal stem cell (MSC)-based transplantation is a promising therapeutic approach
for bone regeneration and repair. In the realm of therapeutic bone regeneration, the defect …

Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a
computational platform that integrates the analysis of copy number variations and somatic …

Histone modifications serve as regulatory marks that are instrumental for the control of
transcription and chromatin architecture. Strict regulation of gene expression patterns is …

The polycomb group (PcG) proteins are essential for the normal development of multicellular
organisms. They form multi-protein complexes that work as transcriptional repressors of …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …