Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and
primary sclerosing cholangitis (PSC), are manifested as an impairment of normal bile flow …

Primary biliary cirrhosis, a slowly progressive autoimmune liver disease characterized by
portal inflammation and an immune-mediated destruction of the intrahepatic bile ducts …

This American Association for the Study of Liver Diseases (AASLD) 2018 Practice Guidance
on Primary Biliary Cholangitis (PBC) is an update of the PBC guidelines published in 2009 …

Practice Guidelines 1;(3) guideline policies, including the AASLD Policy on the
Development and Use of Practice Guidelines and the American Gastroenterological …

Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by clinical
homogeneity among patients, an overwhelming female predominance, production of a …

Bile acids are steroids generated at the interface of host and intestinal microbiota. While
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by
autoimmune destruction of small to medium size intrahepatic bile ducts. The etiology of PBC …

Primary biliary cirrhosis is a chronic liver disease characterised by intrahepatic bile-duct
destruction, cholestasis, and, in some cases, cirrhosis. Evidence supporting the autoimmune …

The liver is the largest organ in the body and is generally regarded by non-immunologists as
not having lymphoid function. However, such is far from accurate. This review highlights the …

Cholestatic liver disorders are caused by genetic defects, mechanical aberrations, toxins, or
dysregulations in the immune system that damage the bile ducts and cause accumulation of …