Mutational robustness and the role of buffer genes in evolvability
MT Tawfeeq, K Voordeckers, P van den Berg… - The EMBO …, 2024 - embopress.org
Organisms rely on mutations to fuel adaptive evolution. However, many mutations impose a
negative effect on fitness. Cells may have therefore evolved mechanisms that affect the …
negative effect on fitness. Cells may have therefore evolved mechanisms that affect the …
Contributions of mutation and selection to regulatory variation: lessons from the Saccharomyces cerevisiae TDH3 gene
PJ Wittkopp - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
Heritable variation in gene expression is common within and among species and
contributes to phenotypic diversity. Mutations affecting either cis-or trans-regulatory …
contributes to phenotypic diversity. Mutations affecting either cis-or trans-regulatory …
Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes
X Zhou, A Hilk, NV Solis, N Pereira De Sa… - PLoS …, 2024 - journals.plos.org
Ergosterol is essential for fungal cell membrane integrity and growth, and numerous
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …
Strategic approaches for designing yeast strains as protein secretion and display platforms
Yeast has been established as a versatile platform for expressing functional molecules,
owing to its well-characterized biology and extensive genetic modification tools. Compared …
owing to its well-characterized biology and extensive genetic modification tools. Compared …
Tdh3 and Rom2 are functional modulators of a conserved condensate-resident RNA-binding protein, Scd6 in Saccharomyces cerevisiae
C Togra, R Dhage, PI Rajyaguru - Genetics, 2024 - academic.oup.com
RGG-motif proteins play a crucial role in determining mRNA fate. Suppressor of clathrin
deficiency 6 (Scd6) is a conserved RGG-motif containing RNP condensate-resident …
deficiency 6 (Scd6) is a conserved RGG-motif containing RNP condensate-resident …
[HTML][HTML] Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypes
X Zhou, A Hilk, NV Solis, BM Hogan, TA Bierbaum… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Ergosterol is essential for fungal cell membrane integrity and growth, and numerous
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …