The synthesis of seven-and eight-membered rings by radical strategies
XC Yu, CC Zhang, LT Wang, JZ Li, T Li… - Organic Chemistry …, 2022 - pubs.rsc.org
Seven-and eight-membered rings widely exist in natural products and drugs. Considering
the transition state nonbonding interactions and torsional strains, the flexible conformations …
the transition state nonbonding interactions and torsional strains, the flexible conformations …
Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …
industry a poor public reputation, despite their undisputable importance to society …
Asymmetric induction and enantiodivergence in catalytic radical C–H amination via enantiodifferentiative H-atom abstraction and stereoretentive radical substitution
Control of enantioselectivity remains a major challenge in radical chemistry. The emergence
of metalloradical catalysis (MRC) offers a conceptually new strategy for addressing this and …
of metalloradical catalysis (MRC) offers a conceptually new strategy for addressing this and …
Synthesis of cyclohexanones by a tandem photocatalyzed annulation
AV Bay, EJ Farnam, KA Scheidt - Journal of the American …, 2022 - ACS Publications
The rapid synthesis of cyclic scaffolds is of high importance to the chemistry community.
Strategies for the convergent synthesis of substituted carbocycles and heterocycles remain …
Strategies for the convergent synthesis of substituted carbocycles and heterocycles remain …
Enantioconvergent amination of racemic tertiary C–H bonds
Racemization is considered to be an intrinsic stereochemical feature of free radical
chemistry as can be seen in traditional radical halogenation reactions of optically active …
chemistry as can be seen in traditional radical halogenation reactions of optically active …
Asymmetric radical process for general synthesis of chiral heteroaryl cyclopropanes
A highly efficient catalytic method has been developed for asymmetric radical
cyclopropanation of alkenes with in situ-generated α-heteroaryldiazomethanes via Co (II) …
cyclopropanation of alkenes with in situ-generated α-heteroaryldiazomethanes via Co (II) …
Enantioselective radical construction of 5-membered cyclic sulfonamides by metalloradical C–H amination
Both arylsulfonyl and alkylsulfonyl azides can be effectively activated by the cobalt (II)
complexes of D 2-symmetric chiral amidoporphyrins for enantioselective radical 1, 5-C–H …
complexes of D 2-symmetric chiral amidoporphyrins for enantioselective radical 1, 5-C–H …
Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene-transfer reactions
We report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out
carbene-transfer reactions using a lactone-based carbene precursor. By simply altering the …
carbene-transfer reactions using a lactone-based carbene precursor. By simply altering the …
Enzymatic kinetic resolution by addition of oxygen
LA Harwood, LL Wong… - Angewandte Chemie …, 2021 - Wiley Online Library
Kinetic resolution using biocatalysis has proven to be an excellent complementary
technique to traditional asymmetric catalysis for the production of enantioenriched …
technique to traditional asymmetric catalysis for the production of enantioenriched …
Catalytic Radical Process for Enantioselective Amination of C(sp3)−H Bonds
A new catalytic radical system involving CoII‐based metalloradical catalysis is effective in
activating sulfamoyl azides for enantioselective radical 1, 6‐amination of C (sp3)− H bonds …
activating sulfamoyl azides for enantioselective radical 1, 6‐amination of C (sp3)− H bonds …