Evinacumab for pediatric patients with homozygous familial hypercholesterolemia
A Wiegman, S Greber-Platzer, S Ali, MD Reijman… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic
disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) …
disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) …
[HTML][HTML] Closing the gaps in care of dyslipidemia: Revolutionizing management with digital health and innovative care models
SJ Apple, R Clark, J Daich, ML Gonzalez… - Reviews in …, 2023 - ncbi.nlm.nih.gov
Although great progress has been made in the diagnostic and treatment options for
dyslipidemias, unawareness, underdiagnosis and undertreatment of these disorders remain …
dyslipidemias, unawareness, underdiagnosis and undertreatment of these disorders remain …
Newborn screening for lipid disorders
Historically, newborn screening for lipid disorders was not done for many reasons, but new
research has developed testing methods that may successfully identify common and rare …
research has developed testing methods that may successfully identify common and rare …
Contemporary lipid-lowering management and risk of cardiovascular events in homozygous familial hypercholesterolaemia: insights from the Italian LIPIGEN Registry
L D'Erasmo, S Bini, M Casula, M Gazzotti… - European Journal of …, 2024 - academic.oup.com
Aims The availability of novel lipid-lowering therapies (LLTs) has remarkably changed the
clinical management of homozygous familial hypercholesterolaemia (HoFH). The impact of …
clinical management of homozygous familial hypercholesterolaemia (HoFH). The impact of …
Long-term outcomes of liver transplantation for homozygous familial hypercholesterolaemia in Australia and New Zealand
Background and aims Homozygous familial hypercholesterolaemia (FH) causes severe
cardiovascular disease from childhood. Conventional drug therapy is usually ineffective; …
cardiovascular disease from childhood. Conventional drug therapy is usually ineffective; …
Universal paediatric screening for familial hypercholesterolaemia
MP McGowan, M Cuchel - The Lancet, 2024 - thelancet.com
Familial hypercholesterolaemia is a common, autosomal, semidominant genetic disorder
that is characterised by increased LDL cholesterol (LDL-C) from birth and, if left untreated …
that is characterised by increased LDL cholesterol (LDL-C) from birth and, if left untreated …
A machine-learning algorithm using claims data to identify patients with homozygous familial hypercholesterolemia
Homozygous familial hypercholesterolemia (HoFH) is an underdiagnosed and undertreated
ultra-rare disease. We utilized claims data from the Komodo Healthcare Map database to …
ultra-rare disease. We utilized claims data from the Komodo Healthcare Map database to …
Evinacumab: Mechanism of action, clinical, and translational science
R Dingman, S Bihorel, V Gusarova… - Clinical and …, 2024 - Wiley Online Library
Homozygous familial hypercholesterolemia (HoFH) is a rare and serious genetic condition
characterized by premature cardiovascular disease due to severely elevated low‐density …
characterized by premature cardiovascular disease due to severely elevated low‐density …
USPSTF Recommendation on Screening for Lipid Disorders in Children and Adolescents
MP McGowan, M Cuchel, PC Lee - JAMA, 2023 - jamanetwork.com
To the Editor The Agency for Healthcare Research and Quality describes the USPSTF as
follows:“The USPSTF works to improve the health of people nationwide by making …
follows:“The USPSTF works to improve the health of people nationwide by making …
[HTML][HTML] It is Time to Screen for Homozygous Familial Hypercholesterolemia in the United States
Homozygous familial hypercholesterolemia (HoFH) is an ultra-rare inherited condition that
affects approximately one in 300,000 people. The disorder is characterized by extremely …
affects approximately one in 300,000 people. The disorder is characterized by extremely …