Since the start of the COVID-19 pandemic, numerous variants of SARS-CoV-2 have been
reported worldwide. The advent of variants of concern (VOCs) raises severe concerns amid …

The COVID-19 pandemic has been accompanied by SARS-CoV-2 evolution and
emergence of viral variants that have far exceeded initial expectations. Five major variants of …

In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These
variants convergently acquired amino acid substitutions at critical residues in the spike …

Host–pathogen interactions and pathogen evolution are underpinned by protein–protein
interactions between viral and host proteins. An understanding of how viral variants affect …

SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD)
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …

Continued evolution and adaptation of SARS-CoV-2 has led to more transmissible and
immune-evasive variants with profound impacts on the course of the pandemic. Here I …

High transmissibility is a hallmark of the Omicron variant of SARS-CoV-2. Understanding the
molecular determinants of Omicron's transmissibility will impact development of intervention …

SARS-CoV-2 has adapted in a stepwise manner, with multiple beneficial mutations
accumulating in a rapid succession at origins of VOCs, and the reasons for this are unclear …

Allosteric mechanisms are commonly employed regulatory tools used by proteins to
orchestrate complex biochemical processes and control communications in cells. The …

Continued evolution of SARS-CoV-2 generates variants to challenge antibody immunity
established by infection and vaccination. A connection between population immunity and …