Current understanding of modes of action of multicomponent bioactive phytochemicals: Potential for nutraceuticals and antimicrobials

M Wink - Annual Review of Food Science and Technology, 2022 - annualreviews.org
Plants produce a diversity of plant secondary metabolites (PSMs), which function as defense
chemicals against herbivores and microorganisms but also as signal compounds. An …

Anti-aging effects and mechanisms of anthocyanins and their intestinal microflora metabolites

B Wang, X Tang, B Mao, Q Zhang, F Tian… - Critical Reviews in …, 2024 - Taylor & Francis
Aging, a natural and inevitable physiological process, is the primary risk factor for all age-
related diseases; it severely threatens the health of individuals and places a heavy burden …

The role of Caenorhabditis elegans in the discovery of natural products for healthy aging

B Kirchweger, J Zwirchmayr, U Grienke… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2012 to 2023 The human population is aging. Thus, the greatest risk factor for
numerous diseases, such as diabetes, cancer and neurodegenerative disorders, is …

Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced …

A Lipecz, T Csipo, S Tarantini, RA Hand, BTN Ngo… - Geroscience, 2019 - Springer
Aging is a major risk factor for vascular cognitive impairment and dementia (VCID). Recent
studies demonstrate that cerebromicrovascular dysfunction plays a causal role in the …

Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies in Caenorhabditis elegans

EY Hernández-Cruz, D Eugenio-Pérez… - ACS …, 2023 - ACS Publications
Oxidative stress is a natural physiological process where the levels of oxidants, such as
reactive oxygen species (ROS) and nitrogen (RNS), exceed the strategy of antioxidant …

Geroprotective potential of microbiome modulators in the Caenorhabditis elegans model

BC Miller, M Mathai, H Yadav, S Jain - GeroScience, 2024 - Springer
Aging is associated with cellular and physiological changes, which significantly reduce the
quality of life and increase the risk for disease. Geroprotectors improve lifespan and slow the …

Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise

MD Navarro-Hortal, JM Romero-Márquez… - Critical Reviews in …, 2023 - Taylor & Francis
As the number of older people has grown in recent decades, the search for new approaches
to manage or delay aging is also growing. Among the modifiable factors, diet plays a crucial …

Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review

Y Ye, Q Gu, X Sun - … Reviews in Food Science and Food Safety, 2020 - Wiley Online Library
Aging is an inevitable process characterized by the accumulation of degenerative damage,
leading to serious diseases that affect human health. Studies on aging aim to develop pre …

Alaskan berry extracts promote dermal wound repair through modulation of bioenergetics and integrin signaling

D Esposito, J Overall, MH Grace… - Frontiers in …, 2019 - frontiersin.org
Various wild berry species endemic to Alaska and the circumpolar North that exhibit unique
medicinal properties have long been appreciated by indigenous Arctic communities …

A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans

J Zwirchmayr, B Kirchweger, T Lehner, A Tahir… - Scientific reports, 2020 - nature.com
In this study a robust, whole organism screening based on Caenorhabditis elegans is
presented for the discovery of natural products (NP) with beneficial effects against obesity …