T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

T-cell acute lymphoblastic leukemias (T-ALL) are immature lymphoid tumors localizing in the
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases
of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the …

To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we
combined expression profiling of 117 pediatric patient samples and detailed molecular …

It has been almost a quarter century since it was first appreciated that a class of oncogenes
contained in rapidly transforming avian retroviruses encoded DNA-binding transcription …

T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous group of hematological
tumors composed of distinct subtypes that vary in their genetic abnormalities, gene …

SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential
transcription factor in normal and malignant hematopoiesis. It is required for specification of …

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of
human T cell acute lymphoblastic leukemia (T-ALL) and initiates T-ALL in mouse models. By …

LIM-domain proteins are a large family of proteins that are emerging as key molecules in a
wide variety of human cancers. In particular, all members of the human LIM-domain-only …

Cognate antigen signal controls CD8+ T cell priming, expansion size and effector versus
memory cell fates, but it is not known if and how it modulates the functional features of …