Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …

Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …

Cardiovascular diseases are the number one cause of death worldwide and greatly impact
quality of life and medical costs. Enormous effort has been made in research to obtain new …

Nitric oxide (NO) is one of the most pleiotropic signaling molecules at systemic and cellular
levels, participating in vascular tone regulation, cellular respiration, proliferation, apoptosis …

Epidemiological, genetic, transcriptome, postmortem, peripheral biomarker, and therapeutic
studies of schizophrenia all point to a dysregulation of both innate and adaptive immune …

Each differentiated cell type has its own epigenetic signature, which reflects its genotype,
developmental history, and environmental influences, and is ultimately reflected in the …

Preeclampsia and intrauterine growth restriction (IUGR) are two of the most common
adverse pregnancy outcomes, but their underlying causes are mostly unknown. Although …

Throughout in utero development, the placenta plays a key role in controlling growth and
development. The placenta acts not only as a gatekeeper of nutrient and waste exchange …

Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter
gestational age, and increased risk of maternal and offspring cardiovascular diseases later …