Enteroviruses are a major source of human disease, particularly in neonates and young
children where infections can range from acute, self-limited febrile illness to meningitis …

Abstract As World Health Organization advocates, the global burden of sanitation related
disease and access to safely managed sanitation and safely treated wastewater should be …

Background The prognosis of patients with recurrent World Health Organization (WHO)
grade IV malignant glioma is dismal, and there is currently no effective therapy. We …

Activating intra-tumor innate immunity might enhance tumor immune surveillance.
Virotherapy is proposed to achieve tumor cell killing, while indirectly activating innate …

A cornerstone of the global initiative to eradicate polio is the widespread use of live and
inactivated poliovirus vaccines in extensive public health campaigns designed to prevent …

Background Outcomes of recurrent paediatric high-grade glioma are poor, with a median
overall survival of less than 6 months. Viral immunotherapy, such as the polio–rhinovirus …

ABSTRACT In 2014, enterovirus D68 (EV-D68) emerged causing outbreaks of severe
respiratory disease in children worldwide. In a subset of patients, EV-D68 infection was …

Glioma accounts for nearly 80% of all intracranial malignant tumors. It is a major challenge
to society as it is causes to impaired brain function in many patients. Currently, gliomas are …

Introduction: Three major advances have led to increase in length and quality of human life:
increased food production, improved sanitation and induction of specific adaptive immune …

Background Malignant gliomas commandeer dense inflammatory infiltrates with glioma-
associated macrophages and microglia (GAMM) promoting immune suppression, evasion …