It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

The identification of MPTP, a relatively simple compound which causes selective
degeneration of the substantia nigra after systemic administration, has had an a significant …

Background For centuries, agents derived from natural sources (mother nature), especially
plants have been the primary source of medicine. Neem, also referred to as Azadirachta …

Cell-to-cell transport of risk molecules is a highly anticipated pathogenic mechanism in the
initiation and progression of various neurodegenerative diseases. Extracellular exosome …

Parkinson's disease (PD) is a progressive neurodegenerative disorder for which only
symptomatic treatments are available. Both preclinical and clinical studies suggest that …

Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain
endothelial cells have been used to shuttle antibodies and other cargos across the blood …

Azadirachta indica or Neem has been extensively used in the Indian traditional medical
system because of its broad range of medicinal properties. Neem contains many chemically …

Neurotrophins are a family of proteins that play an important role in the regulation of the
growth, survival, and differentiation of neurons in the central and peripheral nervous system …

Perhaps the most important unmet clinical need in Parkinson's disease (PD) is the
development of a therapy that can slow or halt disease progression. Extensive preclinical …

Neurodegenerative disorders are prevalent, complex and devastating conditions, with very
limited treatment options currently available. While they manifest in many forms, there are …