Interleukin-6 in pregnancy and gestational disorders

JR Prins, N Gomez-Lopez, SA Robertson - Journal of reproductive …, 2012 - Elsevier
IL6 is a multifunctional cytokine with pivotal roles in the inflammatory response and in
directing T cell differentiation in adaptive immunity. IL6 is widely expressed in the female …

Tumor necrosis factor‐alpha, interleukin‐6, and interleukin‐10 levels are altered in preeclampsia: a systematic review and meta‐analysis

SY Lau, SJ Guild, CJ Barrett, Q Chen… - American journal of …, 2013 - Wiley Online Library
Problem Published reports testing the association between cytokine levels and
preeclampsia are conflicting. This comprehensive systematic review and meta‐analysis …

Pre‐eclampsia: fitting together the placental, immune and cardiovascular pieces

JL James, GS Whitley, JE Cartwright - The Journal of pathology, 2010 - Wiley Online Library
The success of pregnancy is a result of countless ongoing interactions between the placenta
and the maternal immune and cardiovascular systems. Pre‐eclampsia is a serious …

Placental extracellular vesicles and feto-maternal communication

M Tong, LW Chamley - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The human placenta is an anatomically unique structure that extrudes a variety of
extracellular vesicles into the maternal blood (including syncytial nuclear aggregates …

Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications

I Hromadnikova, K Kotlabova, M Ondrackova… - DNA and cell …, 2015 - liebertpub.com
To demonstrate that pregnancy-related complications are associated with alterations in
placental microRNA expression. Gene expression of 15 C19MC microRNAs (miR-512-5p …

[HTML][HTML] Molecular genetics of preeclampsia and HELLP syndrome—a review

J Jebbink, A Wolters, F Fernando, G Afink… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Preeclampsia is characterised by new onset hypertension and proteinuria and is a major
obstetrical problem for both mother and foetus. Haemolysis elevated liver enzymes and low …

MicroRNAs in preeclampsia

G Skalis, V Katsi, A Miliou, G Georgiopoulos… - Microrna, 2019 - ingentaconnect.com
Preeclampsia (PE) continues to represent a worldwide problem and challenge for both
clinicians and laboratory-based doctors. Despite many efforts, the knowledge acquired …

A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia

C Xie, MZ Yao, JB Liu, LK Xiong - Cytokine, 2011 - Elsevier
Inflammation may play a major role in the pathogenesis of preeclampsia (PE). In this meta-
analysis, we determined whether maternal polymorphisms and serum concentrations of …

Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia

S Goulopoulou, T Matsumoto, GF Bomfim… - Clinical …, 2012 - portlandpress.com
Emerging evidence suggests that in addition to being the 'power houses' of our cells,
mitochondria facilitate effector responses of the immune system. Cell death and injury result …

The role of interleukins in preeclampsia: a comprehensive review

I Bellos, V Karageorgiou, D Kapnias… - American Journal of …, 2018 - Wiley Online Library
Preeclampsia is a multi‐system hypertensive disorder of pregnancy, with significant rates of
maternal and neonatal morbidity. It represents a major cause of preterm birth, as definitive …