Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

Centrosomes are microtubule-organizing centres of animal cells. They influence the
morphology of the microtubule cytoskeleton, function as the base for the primary cilium and …

Centrioles are microtubule-based organelles responsible for forming centrosomes and cilia,
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

In normal human cells, centrosome loss induced by centrinone—a specific centrosome
duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown …

Centrioles are essential for the formation of cilia and flagella. They also form the core of the
centrosome, which organizes microtubule arrays important for cell shape, polarity, motility …