Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

[HTML][HTML] Chronic inflammation and the hallmarks of aging

JJ Baechle, N Chen, P Makhijani, S Winer… - Molecular …, 2023 - Elsevier
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Lupus nephritis

HJ Anders, R Saxena, M Zhao, I Parodis… - Nature reviews Disease …, 2020 - nature.com
Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …

Plasmacytoid dendritic cells: development, regulation, and function

B Reizis - Immunity, 2019 - cell.com
Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-
derived nucleic acids and respond with rapid and massive production of type I interferon …

[HTML][HTML] SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8

V Salvi, HO Nguyen, F Sozio, T Schioppa, C Gaudenzi… - JCI insight, 2021 - ncbi.nlm.nih.gov
The inflammatory and IFN pathways of innate immunity play a key role in the resistance and
pathogenesis of coronavirus disease 2019 (COVID-19). Innate sensors and SARS-CoV-2 …

Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments

HM Nail, CC Chiu, CH Leung, MMM Ahmed… - Journal of biomedical …, 2023 - Springer
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in
the survival of an organism. This communication occurs by different methods, one of which is …

DC-based vaccines for cancer immunotherapy

C Fu, L Zhou, QS Mi, A Jiang - Vaccines, 2020 - mdpi.com
As the sentinels of the immune system, dendritic cells (DCs) play a critical role in initiating
and regulating antigen-specific immune responses. Cross-priming, a process that DCs …

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis

Z Ni, L Kuang, H Chen, Y Xie, B Zhang, J Ouyang… - Cell death & …, 2019 - nature.com
Synovitis, a common clinical symptom for osteoarthritis (OA) patients, is highly related to OA
pathological progression and pain manifestation. The activated synovial macrophages have …

DC-derived exosomes for cancer immunotherapy

Y Yao, C Fu, L Zhou, QS Mi, A Jiang - Cancers, 2021 - mdpi.com
Simple Summary Dendritic cells (DCs)-based cancer vaccines have not succeeded in
generating significant clinical responses despite their capacity to induce host anti-tumor …

[HTML][HTML] Mesenchymal stem cell–derived extracellular vesicles alleviate acute lung injury via transfer of miR-27a-3p

J Wang, R Huang, Q Xu, G Zheng, G Qiu… - Critical Care …, 2020 - journals.lww.com
Objectives: The goal of this study was to determine the role of microRNA transfer in
mediating the effects of mesenchymal stem cell–derived extracellular vesicles in acute lung …