Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the
mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its …

First developed for hematologic disorders, the concept of cancer stem cells (CSCs) was
expanded to solid tumors, including colorectal cancer (CRC). The traditional model of colon …

Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …

The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

Vasculogenic mimicry (VM) refers to the unique capability of aggressive tumor cells to mimic
the pattern of embryonic vasculogenic networks. In the study we demonstrated that CD133 …

CD133 (prominin-1), a 5-transmembrane glycoprotein, has recently been considered to be
an important marker that represents the subset population of cancer stem-like cells. Herein …

Abstract CD133 (prominin‐1) was the first in a class of novel pentaspan membrane proteins
to be identified in both humans and mice, and was originally classified as a marker of …

Lung cancer is the leading cause of cancer mortality worldwide. Despite advances in anti-
cancer therapies such as chemotherapy, radiotherapy and targeted therapies, five-year …

The purpose of the present study was to search for the presence of a tumor‐initiating stem
cell population in renal carcinomas. Based on the recent identification of mesenchymal stem …

The growth and dissemination of tumors rely on an altered vascular network, which supports
their survival and expansion and provides accessibility to the vasculature and a route of …