Recent research has brought about a clear understanding that successful fracture healing is
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments.
Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical …

Human skin is a remarkable organ that sustains insult and injury throughout life. The ability
of skin to expeditiously repair wounds is paramount to survival. With an aging global …

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone
marrow. Currently MSCs may also be isolated from several alternative sources and they …

Bone marrow-derived mesenchymal stem cells (MSC) have unique immunomodulatory and
reparative properties beneficial for allotransplantation cellular therapy. The clinical …

Significance: The number of patients with nonhealing wounds has rapidly accelerated over
the past 10 years in both the United States and worldwide. Some causative factors at the …

Mesenchymal stem cells (MSCs) are multipotent stem cells. In addition to the capacity for
self-renewal and multipotential differentiation, MSCs also have the following characteristics …

Background Brain repair mechanisms fail to promote recovery after stroke, and approaches
to induce brain regeneration are scarce. Mesenchymal stem cells (MSC) are thought to be a …

Abstract Interferon-γ (IFN-γ)-preactivated mesenchymal stem cells (MSC-γ) are highly
immunosuppressive but immunogenic in vivo due to their inherent expression of major …