Oligonucleotide-based therapy has become an alternative to classical approaches in the
search of novel therapeutics involving gene-related diseases. Several mechanisms have …

The last decade has witnessed the blooming of nucleic acids for therapeutic and diagnostic
applications. In the present article, we describe the most important results from our group in …

To use siRNA (small interfering RNA) for gene therapy, a gene delivery system is often
necessary to overcome several challenging requirements including rapid excretion, low …

Efficient intracellular delivery of small-interfering ribonucleic acid (siRNA) to the target organ
or tissues in the body is assumed as the main hurdle for a widespread use of siRNAs in the …

Short interfering RNAs (siRNAs) have tremendous potential as a new class of next-
generation therapeutics; however, their progress is lagging due to issues related to stability …

The main parameters that contribute to non-viral gene delivery are chemical structure and
charge distribution. Indeed, saccharide units have been reported to have specific …

Antisense oligodeoxynucleotides (ODNs) are short synthetic DNA polymers complementary
to a target RNA sequence. They are commonly designed to halt a biological event, such as …

Oligonucleotide-based therapeutics may be one of the most promising approaches for the
treatment of diseases. Although significant progress has been made in developing these …

This book compiles recent research on the modification of nucleic acids. It covers backbone
modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their …

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