It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

The effects of a microgravity environment on the myriad types of immune cells present within
the human body have been assessed both by bench-scale simulation and suborbital …

The capability to directly interrogate intracellular structures inside a single cell for
measurement and manipulation is important for understanding subcellular and suborganelle …

The FLUMIAS (Fluorescence-Microscopic Analyses System for Life-Cell-Imaging in Space)
confocal laser spinning disk fluorescence microscope represents a new imaging capability …

Cells live in a complex and dynamic microenvironment, and a variety of microenvironmental
cues can regulate cell behavior. In addition to biochemical signals, biophysical cues can …

The proper integration of biophysical cues from the cell vicinity is crucial for cells to maintain
homeostasis, cooperate with other cells within the tissues, and properly fulfill their biological …

Cell mechanics is crucial for a wide range of cell functions, including proliferation, polarity,
migration and differentiation. Cells sense external physical cues and translate them into a …

Background Microgravity directly disturbs the reorganization of the cytoskeleton, exerting
profound effects on the physiological process of macrophages. Although it has been …

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …

The organization of eukaryotic genome in the nucleus, a double-membraned organelle
separated from the cytoplasm, is highly complex and dynamic. The functional architecture of …