Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

Recent findings demonstrate that multiple mRNAs are co-regulated by one or more
sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability …

HuR influences gene expression programs and hence cellular phenotypes by binding to
hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular …

Abstract Argonaute 2 (AGO2), the core component of microRNA (miRNA)-induced silencing
complex, plays a compelling role in tumorigenesis and aggressiveness. However, the …

RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of
RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes …

Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …

The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …

RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …

During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …

The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …