Metastasis-initiating cells and ecosystems

J Massague, K Ganesh - Cancer discovery, 2021 - AACR
Metastasis is initiated and sustained through therapy by cancer cells with stem-like and
immune-evasive properties, termed metastasis-initiating cells (MIC). Recent progress …

Collective metastasis: coordinating the multicellular voyage

E Wrenn, Y Huang, K Cheung - Clinical & experimental metastasis, 2021 - Springer
The metastatic process is arduous. Cancer cells must escape the confines of the primary
tumor, make their way into and travel through the circulation, then survive and proliferate in …

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes

C Kenny, R Dilshat, HE Seberg, E Van Otterloo… - PLoS …, 2022 - journals.plos.org
In developing melanocytes and in melanoma cells, multiple paralogs of the Activating-
enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of …

Cancer cell states and emergent properties of the dynamic tumor system

D Barkley, A Rao, M Pour, GS França… - Genome research, 2021 - genome.cshlp.org
Phenotypic heterogeneity within malignant cells of a tumor is emerging as a key property of
tumorigenesis. Recent work using single-cell transcriptomics has led to the identification of …

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation genes but inhibit expression of cell-cell adhesion genes independently of MITF

C Kenny, R Dilshat, H Seberg, EV Otterloo, G Bonde… - bioRxiv, 2021 - biorxiv.org
In developing melanocytes and in melanoma cells, multiple paralogs of the Activating-
enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of …