Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders

M Riazifar, MR Mohammadi, EJ Pone, A Yeri… - ACS …, 2019 - ACS Publications
To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …

Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on …

S Viswanathan, Y Shi, J Galipeau, M Krampera… - Cytotherapy, 2019 - Elsevier
Abstract The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal
Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of …

Biology and therapeutic potential of mesenchymal stem cell‐derived exosomes

Z Xunian, R Kalluri - Cancer Science, 2020 - Wiley Online Library
Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to
differentiate into several cell types. MSC‐based therapy has emerged as a promising …

Insights into the secretome of mesenchymal stem cells and its potential applications

S Eleuteri, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …

[HTML][HTML] Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

S Cosenza, K Toupet, M Maumus, P Luz-Crawford… - Theranostics, 2018 - ncbi.nlm.nih.gov
Objectives: Mesenchymal stem cells (MSCs) release extracellular vesicles (EVs) that display
a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis …

The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity

Y Zhou, Y Yamamoto, Z Xiao, T Ochiya - Journal of clinical medicine, 2019 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …

The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings

M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …

Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment

TL Whiteside - Seminars in immunology, 2018 - Elsevier
Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment
(TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co …